Within how many hours postpartum should RhoGAM be administered to prevent isoimmunization?

RhoGAM should be administered within 72 hours postpartum to effectively prevent isoimmunization in Rh-negative mothers who have given birth to Rh-positive infants. This timeframe is critical as it allows the RhoGAM to neutralize any Rh-positive red blood cells that may have entered the mother's circulation during delivery, thereby preventing her immune system from producing antibodies against the Rh factor.

Administering RhoGAM within this 72-hour window is essential to reduce the risk of Rh incompatibility in future pregnancies. If RhoGAM is given after this period, there is a potential for the mother to develop antibodies, which can lead to hemolytic disease of the newborn in subsequent pregnancies. This makes timely administration a vital component of maternal-fetal care in Rh-negative cases.